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Cluster analysis on high dimensional RNA-seq data with applications to cancer research – An evaluation study
Published: 10/12/2019Clustering of gene expression data is widely used to identify novel subtypes of cancer. Plenty of clustering approaches have been proposed, but there is a lack of knowledge regarding their relative me ... Read moreSource: www.rna-seqblog.com -
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Researchers systematically test how accurately RNA sequencing can assign cell identity
Published: 10/12/2019“Being crabby” might have a whole new meaning. A crab’s nervous system could help scientists learn what causes single neurons in the human brain to... Read moreSource: www.rna-seqblog.com -
Evaluation of differential splicing tools for RNA-seq studies
Published: 6/12/2019Differential splicing (DS) is a post-transcriptional biological process with critical, wide-ranging effects on a plethora of cellular activities and disease processes. To date, a number of computation ... Read moreSource: www.rna-seqblog.com
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CDSeq – A novel complete deconvolution method for dissecting heterogeneous samples using gene expression data
Published: 5/12/2019Quantifying cell-type proportions and their corresponding gene expression profiles in tissue samples would enhance understanding of the contributions of individual cell types to the physiological... Read moreSource: www.rna-seqblog.com -
Researchers use RNA-Seq to discover potential new treatment for parasite disease
Published: 5/12/2019Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine (UMSOM) Institute for Genome Sciences identified a promising novel treatment for lymphatic fila ... Read moreSource: www.rna-seqblog.com -
Rutgers Study Achieves Highest Precision and Lowest Error Rates in mRNA Discoveries Using a Robust Bioinformatics Tool
Published: 4/12/2019A new Rutgers School of Public Health study employs a novel statistical method for discovering full-length sequences of messenger RNA molecules, or mRNA transcripts, with accuracy and high confidence. ... Read moreSource: www.rna-seqblog.com
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SparK: Publication-Quality NGS plotting tool
Published: 4/12/2019While there are sophisticated resources available for displaying NGS data, including the Integrative Genomics Viewer (IGV) and the UCSC genome browser, exporting regions and assembling figures for pub ... Read moreSource: www.rna-seqblog.com -
Efficient depletion of ribosomal RNA for RNA sequencing in planarians
Published: 4/12/2019The astounding regenerative abilities of planarian flatworms prompt steadily growing interest in examining their molecular foundation. Planarian regeneration was found to require hundreds of genes and ... Read moreSource: www.rna-seqblog.com -
Algorithm first to automate the search for anomalies in RNA-Seq data
Published: 4/12/2019Computational biologists at Carnegie Mellon University have devised an algorithm to rapidly sort through mountains of gene expression data to find unexpected phenomena that might merit further study. ... Read moreSource: www.rna-seqblog.com
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RNA-Seq perspectives to improve clinical diagnosis
Published: 3/12/2019In recent years, high-throughput next-generation sequencing technology has allowed a rapid increase in diagnostic capacity and precision through different bioinformatics processing algorithms, tools, ... Read moreSource: www.rna-seqblog.com -
RNA-Seq reveals autism-related mutations in aging brains of Alzheimer’s patients
Published: 2/12/2019Significant overlap found between Alzheimer’s-related mutations and those producing autism and related intellectual disabilities, TAU researchers say Researchers believe that autism is caused by ... Read moreSource: www.rna-seqblog.com -
Exploring data-driven analysis of spatially resolved transcriptomes in situ and in single cells
Published: 27/11/2019RNA-sequencing offers the possibility to analyze the expression of all genes in a sample. However, the spatial information of gene expression is lost. In the... Read moreSource: www.rna-seqblog.com
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By exploiting RNA-Seq data, researchers expand our understanding of the pathogenesis of leishmaniasis
Published: 27/11/2019For patients with cutaneous leishmaniasis, a skin infection transmitted by a sand fly that can lead to painful and disfiguring ulcers, treatment can be grueling. The first-line therapy offered to many ... Read moreSource: www.rna-seqblog.com -
RNA-Seq Data Analysis Workshop in Berlin (2 – 5 March 2020)
Published: 26/11/2019RNA-Seq Data Analysis Workshop Quality Control, Read Mapping, Visualization and Downstream Analyses Advance your research. Understand RNA-Seq analyses challenges and solve them yourself. In a nutshell ... Read moreSource: www.rna-seqblog.com -
Poly(A) inclusive RNA isoform sequencing (PAIso-seq)
Published: 26/11/2019Message RNA poly(A) tails are vital for their function and regulation. However, the full-length sequence of mRNA isoforms with their poly(A) tails remains undetermined. Now, researchers from the... Read moreSource: www.rna-seqblog.com
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Single-cell RNA-Seq reveals what could be the key to longevity
Published: 26/11/2019Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians—meaning people. ... Read moreSource: www.rna-seqblog.com -
Structural variant calling – the long and the short of it
Published: 22/11/2019Recent research into structural variants (SVs) has established their importance to medicine and molecular biology, elucidating their role in various diseases, regulation of gene expression, ethnic... Read moreSource: www.rna-seqblog.com -
Researchers uncover multiscale transcriptomic networks and key regulators in Parkinson’s disease
Published: 22/11/2019Scientists at the Icahn School of Medicine at Mount Sinai have uncovered new molecular drivers of Parkinson’s disease using a sophisticated statistical technique called multiscale gene network analysi ... Read moreSource: www.rna-seqblog.com
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A benchmarking of pipelines for detecting ncRNAs from RNA-Seq data
Published: 21/11/2019Next-Generation Sequencing (NGS) is a high-throughput technology widely applied to genome sequencing and transcriptome profiling. RNA-Seq uses NGS to reveal RNA identities and quantities in a given sa ... Read moreSource: www.rna-seqblog.com -
RNA sequencing identifies T cells primed for certain allergies or infections
Published: 21/11/2019Researchers develop a method to isolate and sequence the RNA of T cells that react to a specific target. When your immune system is exposed to a... Read moreSource: www.rna-seqblog.com -
Next-generation sequencing of dsRNA is greatly improved by treatment with the inexpensive denaturing reagent DMSO
Published: 20/11/2019dsRNA is the genetic material of important viruses and a key component of RNA interference-based immunity in eukaryotes. Previous studies have noted difficulties in determining the sequence of dsRNA.. ... Read moreSource: www.rna-seqblog.com