A novel constrained reconstruction model towards high-resolution sub-tomogram averaging

Published: 16/10/2019
A novel constrained reconstruction model towards high-resolution sub-tomogram averaging
Source: ACADEMIC.OUP.COM

Abstract Motivation Electron tomography (ET) offers a unique capacity to image biological structures in situ . However, the resolution of ET reconstructed tomograms is not comparable to that of the single-particle cryo-EM. If many copies of the object of interest are present in the tomograms, their structures can be reconstructed in the tomogram, picked, aligned and averaged to increase the signal

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